Pathobiology for Investigators, Students, and Academicians (PISA)
Young Investigators Virtual Meeting

ALL Session Times are Eastern Standard Time (ET)

How To Find Your Local Time For a Session

If you are in the Central time zone, subtract 1 hour, e.g., 11:00 AM ET is 10:00 AM CT
If you are in the Mountain time zone, subtract 2 hours, e.g., 11:00 AM ET is 9:00 AM MT
If you are in the Pacific time zone, subtract 3 hours, e.g., 11:00 AM ET is 8:00 AM PT

Click on the links below to go directly to that day's program information 

Tuesday   |   Wednesday   |   Thursday  

Tuesday, November 5, 2024 

Welcome to the PISA 2024 Virtual Meeting
Satdarshan (Paul) Singh Monga, MD, ASIP President
University of Pittsburgh

SESSION 1 - Liver Pathobiology Young Investigator Short Talks
2:00 - 3:00 PM

• 2:00 - 2:15 PM 
  Abstract 1 - HNF1B Controls the Cell’s Commitment to Hepatic Fat
  Carla Martinez-Morant, Francesca Di-Furio, Stephen A. Duncan
  Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC
   
• 2:15 - 2:30 PM
  Abstract 2 - Role of Autophagy in Hepatic Proteome and its Post-Translational Modification
  Kamal Baral, Leah Spade, Arissa Mercer, Sadisha Shrestha S, Arya A Chandrasekhar, Gang Liu, Xiao-Ming Yin, and Bilon Khambu
  Department of Pathology and Laboratory Medicine, School of Medicine, Tulane University, New Orleans, LA
   
• 2:30 - 2:45 PM 
  Abstract 3 - Role of DEK in Liver Fibrosis
  Arya Chandrasheker^1,2, Niani Bailey¹, Nickol Wahby¹, Kamal Baral¹, Leah Spade¹, Arissa Mercer¹, and Bilon Khambu^{1
  1}Tulane School of Science and Engineering, Tulane University, New Orleans, LA; ²Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA    
                        
• 2:45 - 3:00 PM
  Abstract 4 - Neutrophil Infiltration via STING Signaling Promotes Inflammation in Primary Sclerosing Cholangitis
  Abid Anwar^1,2, Maleeha Kalaiger^1,2, Sofia Jerez Ortega^1,2, Jordan Young^1,2, Usman Yaqoob1,², Kaitlin Friesland^1,2, Robert C. Huebert^1,2,3, Nidhi Jalan-Sakrikar^{1,2,3
  1}Division of Gastroenterology and Hepatology, ²Gastroenterology Research Unit, ³Center for Cell Signaling in Gastroenterology; Mayo Clinic, Rochester, MN
   
• 3:00 - 3:15 PM
  Abstract 5 - Targeting CRM1-HMGB1 Nuclear Translocation in Type 2 Diabetes-Driven Metabolic Dysfunction Associated Steatotic Liver Disease
  Prabu Paramasivam^1,2, Brittany Coffman³, Jaya Rajaiya⁴, Satdarshan Paul Monga⁵, Roberto Ivan Mota Alvidrez^{1,2,6,7,8
  1}Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM; ²Clinical and Translational Sciences Center, University of New Mexico, Albuquerque, NM; ³Raymond G. Murphy New Mexico Veterans Affairs Medical Center, Albuquerque, NM; ⁴Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM; ⁵Department of Pathology, University of Pittsburgh School of Medicine and Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA; ⁶Biomedical Engineering Department, University of New Mexico, Albuquerque, NM; ⁷Cardiovascular and Metabolic Diseases (CVMD) Signature Program, University of New Mexico, Albuquerque, NM; ⁸Autophagy, Inflammation, Metabolism CoBRE, University of New Mexico, Albuquerque, NM
   
• 3:15 - 3:30 PM
  Abstract 6 - Hepatocyte-Specific MET Deletion Exacerbates Liver Damage and Impairs Regenerative Response in Acetaminophen-Induced Hepatotoxicity Model
  Siddhi Jain, Ranjan Mukherjee, Gillian Williams, George K. Michalopoulos, Wendy M. Mars, and Bharat Bhushan
  Department of Pathology, School of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA
   
• 3:30 - 3:45 PM
  Abstract 7 - Targeting EGFR as a Novel Strategy for Treating Acetaminophen Hepatotoxicity
  Gillian Williams, Siddhi Jain, Ranjan Mukherjee, and Bharat Bhushan
  Department of Pathology and Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine,
  Pittsburgh, PA
   
• 3:45 - 4:00 PM
  Abstract 8 - Effects of Hepatocyte-Specific EGFR and ERBB3 Deletion in Murine Fast-Food Diet Model of MASLD
  Shehnaz Bano, Matthew A. Copeland, John W. Stoops, Anne Orr, Joseph Locker, Wendy M. Mars, George K. Michalopoulos, and Bharat Bhushan
  Department of Pathology and Pittsburgh Liver Research Center, School of Medicine, University of Pittsburgh,
  Pittsburgh, PA

SESSION 2 - Wisdom From The Pros: Navigating Different Career Paths in Biomedical Science Moderator: Priscilla Kyi, MS, BS • Medical College of Wisconsin 4:00 - 5:00 PM Session Description: This session will introduce trainees to alternative career options in biomedical medicine. The panel members will discuss how trainees can navigate career paths outside academia. The panelists will also answer questions on the benefits and challenges of pursuing these careers.

4:00 PM - 4:20 PM            4:20 PM - 4:40 PM                   4:40 PM - 5:00 PM

Patent Agent Peter Volberding, PhD • Quarles & Brady Dr. Peter Volberding assists in the preparation and prosecution of patent applications, with a focus on biotechnology. He leverages his background as a bench scientist in the fields of immunology, cell biology and biochemistry, in combination with a creative and collaborative approach to patent drafting and prosecution, to secure patent protection for clients’ innovations. Dr. Volberding has experience drafting and prosecuting patent applications related to vaccines, adjuvants, diagnostic assays, small molecule pharmaceuticals, siRNA, cellular therapies, antibodies, chimeric antigen receptor (CAR) T cells, nanoparticles and CRISPR related technologies. His dissertation focused on the mechanisms by which the immune system regulates inflammatory T cell responses to chronic viral infections. In addition, Dr. Volberding has experience working in a leading biomedical research institution's technology transfer office. Medical Writer Chris Goetz, PhD • Medtronic Chemist turned biomedical PhD scientist that studied the epigenetic mechanisms that influence human health and disease. Extensive research experience in the fields of biochemistry, biology, and chemical biology, and have applied biophysical, cellular biological, chemical, and computational approaches to interrogate complex scientific questions. Particularly interested in translational research, wherein scientific innovations can be utilized in the clinic, leading to impactful, efficacious patient outcomes and promote overall patient well-being. Dr. Goetz is a scientific communicator working as a Senior Medical Writer at Medtronic within the Minimally Invasive Therapies Group (MITG), Clinical Research and Medical Science (CRMS), and Surgical operating unit. Support clinical and regulatory activities for the Medtronic hernia mesh portfolio. He has experience achieving compliance with the EU MDR, FDA, TGA, etc. Questions & Answers

SESSION 3 - Cardiovascular and Pulmonary Disease Young Investigator Short Talks
5:00 - 6:00 PM

• 5:00 - 5:15 PM
  Abstract 9 - Endothelial Senescence Mediates Hypoxia-induced Vascular Remodeling in the Lung
  Priscilla Kyi^1,2, Mrudula Joshi^1,2, Mikaela Scheer¹, Tadanori Mammoto^1,3, and Akiko Mammoto^{1,2?
  1}Department of Pediatrics, ²Department of Cell Biology, Neurobiology and Anatomy, and ³Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 
   
• 5:15 - 5:30 PM 
  Abstract 10 - Sex-Dependent Differences in Lung Vascular Regeneration
  Mrudula Joshi^1,2, Priscilla Kyi^1,2, Mikaela Scheer¹, Tadanori Mammoto^1,3, and Akiko Mammoto^{1,2
  1}Department of Pediatrics, ²Department of Cell Biology, Neurobiology and Anatomy, and ³Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
   
• 5:30 - 5:45 PM 
  Abstract 11 - Endothelial Cell STING Contributes to Capillary Rarefaction and Systolic Dysfunction Induced by Cardiac Pressure Overload
  Erin Sanders¹, Noah Wagner¹, Abraham L. Bayer¹, Sasha Smolgovsky¹, Brandon Theall¹, Mark Aronovitz¹, Robert Blanton², Kuljeet Kaur¹, and Pilar Alcaide^{1
  1}Department of Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA; ²Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA
   
• 5:45 - 6:00 PM
  Abstract 12 - Differential Contributions of Cell Specific STING to the T-Cell Immune Response in Doxorubicin Cardiotoxicity
  Abraham L. Bayer, Erin Sanders, Noah Wagner, Sasha Smolgovsky, and Pilar Alcaide
  Department of Immunology, Tufts University, Boston MA

6:00 PM
Meeting Adjournment 

Wednesday, November 6, 2024

SESSION 4 - More Than a Scientist: Maintaining Life Outside of the Lab Moderator: Sarah Dooley, BS • Medical University of South Carolina 2:00 - 3:00 PM Session Description: This session will center on maintaining relationships and activities outside academic and research responsibilities. The panel members will talk about their challenges, how they define work-life balance, and their advice on overcoming difficulties.

2:00 - 2:15 PM   2:15 - 2:30 PM   2:30 - 2:45 PM           2:45 - 3:00 PM

Pre-Doctoral Trainee Allison Troutman • Medical University of South Carolina Post-Doctoral Fellow Cortney Gensemer, PhD • Medical University of South Carolina Tenured Faculty Mary Frey, PhD • Children's Hospital of Los Angeles Dr. Frey joined CHLA’s Division of Pediatric Gastroenterology, Hepatology and Nutrition in 2010. He is an internationally recognized expert in the cell-cell signaling mechanisms that control regeneration in the intestine after injury. His primary research focus is on how growth factor-initiated signals dynamically regulate the balance of stem and differentiated cells in the lining of the gut, and how this balance is disturbed in inflammatory bowel disease. Dr. Frey will continue to serve in his other leadership positions as Director of the CHLA Samuels Family LA-HIP Program and Director of the USC PIBBS interdisciplinary PhD program. Questions & Answers

SESSION 5 - Inflammation and Ophthalmology Young Investigator Short Talks
3:00 - 5:00 PM

• 3:00 - 3:15 PM 
  Abstract 13 - Exploring the Effects of Epigallocatechin-3-Gallate on the Disaggregation of Serum Amyloid A1 Fibrils
  Natalie G. Horgan¹, Anabela Djurovic-topalovic¹, Hannah IR Charles¹, Natsumi Kobayashi², Tomoaki Murakami², Jessica S. Fortin^{1
  1}Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette IN; ²Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
   
• 3:15 - 3:30 PM 
  Abstract 14 - Persisting Neuroinflammation After 18-weeks in SARS-CoV-2 Infected African Green Monkeys
  Meredith Mayer¹, Linh Hellmers¹, Anne Le², Jason Dufour^3,4, Lara Doyle-Meyers^3,4, Jay Rappaport^1,5, Kasi Russel-Lodigue^3,4, and Tracy Fischer^{1,5
  1}Tulane National Primate Research Center, Division of Comparative Pathology, Covington, LA; ²Gigantest, Baltimore, MD; ³Tulane Nation Primate Research Center, Division of Veterinary Medicine, Covington, LA; ⁴Tulane University School of Medicine, Department of Medicine, New Orleans, LA; ⁵Tulane University School of Medicine, Department of Immunology and Microbiology, New Orleans, LA
   
• 3:30 - 3:45 PM
  Abstract 15 - High-Intensity Interval Training Decreases Circulating HMGB1 in Individuals with Insulin Resistance; Plasma Lipidomics Identifies Associated Cardiometabolic Benefits
  Gabriela Martinez Bravo^1,2,3†, Prabu Paramasivam^1,3†, Gabriella F. Bellissimo⁴, Quiteria Jacquez^1,3, Huayu Zheng¹, Fabiano Amorim⁴, and Roberto Ivan Mota Alvidrez^{1,2,3,5,6
  1}Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM; ²Biomedical Engineering Department, University of New Mexico, Albuquerque, NM; ³Clinical and Translational Sciences Center, University of New Mexico, Albuquerque, NM; ⁴Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM; ⁵Cardiovascular and Metabolic Diseases (CVMD) Signature Program, University of New Mexico, Albuquerque, NM; ⁶Autophagy, Inflammation, Metabolism CoBRE, University of New Mexico, Albuquerque, NM
  †Authors served as co-first authors
   
• 3:45 - 4:00 PM
  Abstract 16 - Epigenetic Changes and Photoreceptor Neuroprotection in a Mouse Retinitis Pigmentosa Model
  Lu Huang^1,2, Lydia Tai Wai², Kin-Sang Cho², Ajay Ashok², Maximilian Braun², Menglu Yang², Karen Chang², Anton Lennikov², Sarita Pooranawattanakul², Julie Chen², Farris Elzaridi², Hio Tong Kam², Shuhong Jiang², Yizhen Tang², Qingfeng Li¹, and Dong Feng Chen^{2
  1}Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ²Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA
   
• 4:00 - 4:15 PM
  Abstract 17 - Deciphering Pathogenic Cytokine Interplay in Retinal Inflammation, Angiogenesis and Fibrosis: A Transcriptomic Approach
  Fergus McLellan¹, Pei Qin Ng², Kelvin Huang¹, Pete A. Williams³, and Daisy Y. Shu^{1
  1}School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia; ²Department of Plant Science, University of Cambridge, Downing Street, Cambridge CB2 3EA, Cambridgeshire, UK; 3Division of Eye and Vision, Department of Clinical Neuroscience, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden
   
• 4:15 - 4:30 PM
  Abstract 18 - From Brain to Eye: Repurposing Dimethyl Fumarate to Target Vascular Endothelial Growth Factor-Induced Angiogenesis in Retinal Endothelial Cells
  Kelvin Huang¹, Pei Qin Ng^2,3, Fergus McLellan¹, Mong Linh Vuong^2,4, Alena Appiah², Menglu Yang², Suman Chaudhary², Anton Lennikov², Zhengping Hu², and Daisy Y. Shu^{1
  1}School of Optometry and Vision Science, University of New South Wales, Kensington, New South Wales, Australia; ²Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA; ³University of Cambridge, Cambridge, United Kingdom; ⁴Technische Universität München, Munich, Bavaria, Germany
   

4:30 - 5:00 PM

BREAK

SESSION 6 - Pursuing a Career in Biomedical Research in the US as an International Trainee Moderators: Rodrigo Machado Florentino, PhD • University of Pittsburgh JaNýa Brown • York College of Pennsylvania 5:00 - 6:00 PM Session Description: This session will focus on international trainees’ training and research paths in the United States. The panelists will also share their personal experiences, challenges, and advice on navigating these challenges.

3:30 PM - 4:15 PM (EST)

Janardan K. Reddy Memorial Keynote Lecture “How Inflammation Begets Pathology” William A. Muller, MD, PhD • Northwestern University

SESSION 7 - Cancer Pathobiology and Molecular Diagnostics Young Investigator Short Talks
2:00 - 3:00 PM

• 4:15 PM - 4:30 PM (EST)
  INFL1 - Adipose Tissue Role in Neonatal Sepsis
  Michele J. Alves, Juliet Torres, Silvio Fernandes de Araujo Junior, Paollo Fadda, Jennifer Mele, Catherine Czeisler, and Jose Otero
  Department of Pathology, The Ohio State University, College of Medicine, Columbus, OH
   
• 4:30 PM - 4:45 PM (EST)
  INFL2 - Differentially Methylated Positions After IL-6 in the Endothelium
  Ramon Bossardi Ramos, Nina Martino, and Alejandro Adam
  Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY
   
• 4:45 PM - 5:00 PM (EST)
  INFL3 - Identification and Characterization of a First Series of Small Molecule Inhibitors of Feline Islet Amyloid Polypeptide Aggregation
  Kelsey E. Duggan¹, Kendra N. Nylen², Nurhanis B.M. Isa², Malikah O’Dell², and Jessica S. Fortin^{1,3
  1}College of Veterinary Medicine, Michigan State University, East Lansing, MI, ²Department of Chemistry, College of Natural Science, Michigan State University, East Lansing, MI, ³Current Address - Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN
   
• 5:00 PM - 5:15 PM (EST)
  INFL4 - Identifying the Targets of Perforin Mediated Killing
  Vineet Garlapally, Vandana Chaturvedi, and Michael Jordan
  Department of Pathobiology and Molecular Medicine, University of Cincinnati, Cincinnati Children’s Hospital, Cincinnati, OH
   
• 5:15 PM - 5:30 PM (EST)
  INFL5 - Cationic Antimicrobial Peptide, E35, Reduces LPS-induced Inflammation in Mice
  Joud Mulla¹, Sultan Abdelhamid¹, Zachary Secunda¹, Bashar Al Matour¹, Nijmeh Alsaadi¹, Berthony Deslouches², and Melanie J. Scott^{1
  1}Department of Surgery, University of Pittsburgh, Pittsburgh, PA, ²Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA
   
• 5:30 PM - 5:45 PM (EST)
  INFL6 - Perivascular Macrophages Prime Vascular Endothelial Cells to Promote Neutrophil Adhesion and Transendothelial Migration
  Xingsheng Ren, Jessica M. Urbanczyk, and Ronen Sumagin
  Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
   
• 5:45 PM - 6:00 PM (EST)
  INFL7 - Human L2 Regulates Leukocyte Transmigration at a Unique Step between those Regulated by PECAM and CD99
  Nakisha S. Rutledge, David P. Sullivan, Faith Ogungbe, and William A. Muller
  Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL
   
• 6:00 PM - 6:15 PM (EST)
  INFL8 - Interplay Between TNFα-induced Inflammation and Metabolic Dysfunction in Retinal Pigment Epithelial Cells
  Daisy Y. Shu, Erik R. Butcher, Emmanuella Nnuji-John, Scott Frank, Rishi Shah, Siwei Cai, Deviprasad Gollapalli, and Magali Saint-Geniez
  Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA

Thursday, November 7, 2024

SESSION 8 - We Have to Talk: Navigating Difficult Conversations in the Lab Moderator: 3:15 - 5:15 PM Session Description:
3:15 - 3:45 PM	Post-Doctoral Fellow Michele Alves, PhD • Florida International University   Instructor Zhengping Hu, MD, PhD • Schepens Eye Research Institute of Massachusetts Eye and Ear   Associate Professor Aimee Shen, PhD • Tufts University Director Lindsay Edwards • Zag Bio (need degree)

SESSION 9 - Gastrointestinal Pathobiology Young Investigator Short Talks
5:30 - 6:45 PM

• 5:30 - 5:45 PM 
  Abstract 24 - Akkermansia Muciniphila Alone Increases Small Intestine Tuft Cell Population via Succinate Production
  Rachel Edens¹, Jordan Rucker¹, Sarah A. Dooley¹, Rachel Stubler¹, Piper McKee¹, Thomas Horvath², Kristen Engevik¹, Melinda A. Engevik^1,3, and Amy C. Engevik^{1
  1}Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC; ²Department of Pathology, Texas Children’s Hospital, Houston TX; ³Department of Microbiology and Immunology, Medical University of South Carolina, SC
   
• 5:45 - 6:00 PM Abstract 25 - Distinct Mucin Profiles are Associated with Inflammation in Ulcerative Colitis Patients
  Alyssa Gutierrez¹, Anna Tingler¹, Amy Engevik¹, and Melinda A. Engevik^{1,2
  1}Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC; ²Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC
   
• 6:00 - 6:15 PM
  Abstract 26 - High Fat Diet Alters Gastric Homeostasis Leading to Metaplasia
  Charulekha Packirisamy¹, Annika Matthiesen², Pooja Pradeep², Janet Boggs², Sarah A. Dooley¹, Rachel Edens¹, Piper McKee¹, Catrina Robinson², and Amy C. Engevik^{1
  1}Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC; ²Department of Neurology, Medical University of South Carolina, Charleston, SC
   
• 6:15 - 6:30 PM
  Abstract 27 - Antibiotic-Induced Alterations in Gut Microbiota and Their Effect on Mucus Production in the Cystic Fibrosis Colon
  Anna Tingler¹, Rachel Bernard², Rachel Edens¹, Jennifer K. Spinler^3,4, Thomas D. Horvath^3,4, Numan Oezguen^3,4, Lisa S. Zhang², Anthony M. Haag^3,4, Amy C. Engevik¹, Daniel C. Payne⁶, Maribeth R. Nicholson², and Melinda A. Engevik^{1,5
  1}Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC; ²Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Monroe Carell Junior Children’s Hospital at Vanderbilt, Nashville TN; ³Department of Pathology, Texas Children’s Hospital, Houston TX; ⁴Department of Pathology & Immunology, Baylor College of Medicine, Houston TX; ⁵Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC; ⁶Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta GA
   
• 6:30 - 6:45 PM
  Abstract 28 - Claudin-23 Expression in Intestinal Epithelial Cells Surrounding Mucosal Wounds Enhances Wound Repair In Vivo
  Kristen M. Lozada-Soto^1,2,3*, Arturo Raya-Sandino^3*, Vicky Garcia-Hernandez3, Miguel Quiros³, Charles A. Parkos³, and Asma Nusrat^{3
  1}Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI; ²Molecular and Cellular Pathology Graduate Program, Rackham Graduate School, University of Michigan, Ann Arbor, MI; ³Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
  *K.L-S. and A.R.-S. contributed equally to the work presented in this abstract.

6:45 - 7:00 PM 7:00 PM

Closing Remarks/Announcement of Award Recipients Satdarshan (Paul) Singh Monga, MD, ASIP President University of Pittsburgh Meeting Adjournment